Bioorganic and Medicinal Chemistry of Fluorine

Foreword. Preface to the English Edition 1 General Remarks on Structural, Physical, and Chemical Properties of Fluorinated Compounds. 1.1 Structural Effects. 1.2 Physical Properties. 1.2.1 Boiling Point. 1.2.2 Surface Tension and Activity. 1.2.3 Polarity-Solubility. 1.2.4 Lipophilicity. 1.3 Effects on Electronic Properties and Reactivity. 1.3.1 Effects of Fluorination on Bond Energies and Reactivity. 1.3.2 Effects of Fluorination on the Electronic Repartition of a Molecule. 1.3.3 Acidity, Basicity, and Hydrogen Bond. 1.3.4 Steric Effects. 1.3.5 Fluorination Effects on the Stability of Reaction Intermediates (Carbocations, Carbanions, and Radicals). References. 2 Overview on the Preparation of Fluorinated…