Systemically inducing trained immunity overcomes solid tumors’ immunosuppressive microenvironment
Radboud University Nijmegen · Angiogenesis Foundation · +12 more institutions
Abstract
Hematopoietic bone marrow progenitors are increasingly implicated as an origin of immunosuppression in cancer. We have previously shown that trained immunity induction using nanomedicine potentiates checkpoint blockade therapy. Here, we studied how this approach's induction of trained immunity systemically overcomes the immunosuppressive tumor microenvironment. We found changes in the tumor microenvironment to mirror functional changes in the hematopoietic system in a melanoma mouse model. Single cell sequencing methods disclosed a shift in the tumor-associated macrophage population from immunosuppressive to antitumorigenic. Uniquely, a trained immunity and checkpoint blockade combination therapy mobilized…
Citation impact
- FWCI
- 35.73
- Percentile
- 99%
- References
- 43
Authors
36- BPBram PriemCorresponding
Radboud University Nijmegen, Angiogenesis Foundation, Radboud University Medical Center, Icahn School of Medicine at Mount Sinai
- LWLisa WillemsenCorresponding
Amsterdam University Medical Centers
- TATom Anbergen
Radboud University Nijmegen, Radboud University Medical Center, Icahn School of Medicine at Mount Sinai
- YVYuri van Elsas
Radboud University Nijmegen, Radboud University Medical Center, Icahn School of Medicine at Mount Sinai
- JDJeroen Deckers
Radboud University Nijmegen, Radboud University Medical Center, Icahn School of Medicine at Mount Sinai
Topics & keywords
- Blockade
- Immunity
- Immunosuppression
- Immune system
- Immune checkpoint
- Haematopoiesis
- Bone marrow
- Immunotherapy
- Good health and well-being