Ionic Liquids in Pharmaceuticals: A Scoping Review of Formulation Strategies
Universidade Federal do Rio Grande do Sul · Universidade Feevale · +2 more institutions
Abstract
Ionic liquids (ILs) have rapidly emerged as multifunctional formulation tools capable of addressing long-standing challenges in drug delivery. This scoping review systematically assessed their pharmaceutical applications through a structured search of Scopus, PubMed, and Web of Science, yielding 1866 records, of which 91 experimental studies met the inclusion criteria. Across oral, injectable, topical, transdermal, nasal, and advanced delivery systems, ILs consistently improved the drug solubility, chemical stability, mucosal permeability, and overall biopharmaceutical performance. Choline- and imidazolium-based ILs were the most frequently investigated, demonstrating favorable safety profiles and significant…
Citation impact
- FWCI
- 23.58
- Percentile
- 100%
- References
- 128
Authors
5Topics & keywords
- Ionic liquid
- Biopharmaceutical
- Drug delivery
- Excipient
- Drug
- Solubility
- Pharmacokinetics