articleGutJan 2, 2026Closed access

Simvastatin in the prevention of recurrent pancreatitis: a triple-blinded randomised clinical trial (the SIMBA trial)

Hospital General Universitario de Alicante Doctor Balmis · Hospital Clínico Universitario de Valladolid · +34 more institutions

PubMed
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Abstract

Background

Recurrent acute pancreatitis (RAP) or acute-on-chronic flares in chronic pancreatitis (CP) have limited preventive options beyond addressing the underlying aetiology. Statins, due to their anti-inflammatory properties, have been proposed as a potential prophylactic treatment.

Objective

We aimed to evaluate whether simvastatin could reduce the recurrence of pancreatitis.

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Funding