Chronic kidney disease induces distinct alterations of macrophage lipid metabolism in a mouse model of atherosclerosis
University of Michigan · Michigan Center for Translational Pathology · +1 more institution
Abstract
Chronic kidney disease (CKD) is associated with altered lipid metabolism and chronic inflammation, which both contribute to an accelerated risk of atherosclerotic cardiovascular disease. Macrophage polarization towards a pro-inflammatory phenotype plays a key role in atherosclerotic cardiovascular disease development and is mediated by a rewiring of macrophage immunometabolism. While prior studies have investigated associations between the systemic lipidome and CKD-accelerated CVD, the impact of CKD on macrophage lipid metabolism remains unknown. In this study, we profiled the macrophage lipidome in mice with and without CKD induced by 5/6 nephrectomy. After 16 weeks of a high-fat diet, thioglycollate-elicited…
Citation impact
- FWCI
- 55.01
- Percentile
- 99%
- References
- 34
Authors
8Topics & keywords
- Lipidome
- Lipid metabolism
- Lipidomics
- Macrophage
- Kidney disease
- Macrophage polarization
- Lipid signaling
- Inflammation
- Good health and well-being