Revitalizing T cells: breakthroughs and challenges in overcoming T cell exhaustion
Second Affiliated Hospital of Zhejiang University · Shaoxing People's Hospital · +8 more institutions
Abstract
T cell exhaustion is a prevalent phenomenon in chronic infections and tumor microenvironments, severely compromising the effectiveness of antitumor and antiviral immunity. In recent years, there has been significant progress in understanding the underlying mechanisms of T cell exhaustion, including external factors and intrinsic cellular changes that drive this dysfunctional state. Key external factors such as persistent antigen exposure, immune checkpoint signaling, and the cytokine milieu, as well as intrinsic changes such as altered metabolic processes, epigenetic modifications, and transcriptional reprogramming, contribute to T cell dysfunction. Emerging therapies targeting T cell exhaustion aim to restore…
Citation impact
- FWCI
- 181.93
- Percentile
- 100%
- References
- 493
Authors
6- YWYiran WuCorresponding
Second Affiliated Hospital of Zhejiang University, Shaoxing People's Hospital, Zhejiang University
- YWYuchen Wu
Second Affiliated Hospital of Zhejiang University, Shaoxing People's Hospital, Zhejiang University
- ZGZhengyu Gao
Hangzhou City University, Zhejiang University
- WYWeixing Yu
Shaoxing People's Hospital
- LZLong Zhang
Nanchang University, Chengdu Medical College, First Affiliated Hospital of Jiangxi Medical College, First Affiliated Hospital of Nanchang University, Zhejiang University
Topics & keywords
- T cell
- Immune system
- Immunotherapy
- Mechanism (biology)
- Cell
- Epigenetics
- Immune checkpoint
- Cytokine