articleMilitary Medical ResearchJan 4, 2026DIAMOND OA

Artificial intelligence in digital pathology diagnosis and analysis: technologies, challenges, and future prospects

First Affiliated Hospital Zhejiang University · Zhejiang University of Science and Technology · +16 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Artificial intelligence (AI) offers transformative potential in pathology, where histopathological images remain the diagnostic gold standard due to their rich morphological and molecular information. While the rapid development of AI-driven computational pathology tools is revolutionizing disease interpretation, these technologies have not yet been systematically evaluated. Therefore, this review systematically evaluates AI applications across the diagnostic continuum, from image preprocessing and tumor classification to prognostic stratification and the discovery of predictive biomarkers. It presents a technical taxonomy of the algorithms and foundation models powering these applications, benchmarking their…

Citation impact

6
total citations
FWCI
146.10
Percentile
100%
References
186
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Authors

30

Topics & keywords

Keywords
  • Digital pathology
  • Interpretability
  • Benchmarking
  • Preprocessor
  • Precision medicine
  • Applications of artificial intelligence
  • Transformative learning
  • Deep learning
UN Sustainable Development Goals
  • Industry, innovation and infrastructure
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