Mitophagy in the pathogenesis and management of disease
École Polytechnique Fédérale de Lausanne · Fudan University
Abstract
Mitophagy, an evolutionarily conserved quality-control process, selectively removes damaged mitochondria to maintain cellular homeostasis. Recent advances in our understanding of the molecular machinery underlying mitophagy - from receptors and stress-responsive triggers to lysosomal degradation - illustrate its key role in maintaining mitochondrial integrity and adapting mitochondrial function to ever-changing physiological demands. In this review, we outline the fundamental mechanisms of mitophagy and discuss how dysregulation of this pathway disrupts mitochondrial function and metabolic balance, driving a wide range of disorders, including neurodegenerative, cardiovascular, metabolic, and immune-related…
Citation impact
- FWCI
- 247.71
- Percentile
- 100%
- References
- 498
Authors
4Topics & keywords
- Mitophagy
- Mitochondrion
- Function (biology)
- Autophagy
- Disease
- Mechanism (biology)
- Model organism
Funding
- NSNational Science Foundation
- EMEuropean Molecular Biology OrganizationAward: ALTF 111-2021
- BFBrightFocus FoundationAward: A2023018F
- ÉPÉcole Polytechnique Fédérale de Lausanne
- SNSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungAwards: 31003A_179435, CRSII5_202302, Sinergia CRSII5_202302, SNSF 31003A_179435
- NNNational Natural Science Foundation of ChinaAwards: 32470816, 82300708, 2021hwyq47
- CPChina Postdoctoral Science FoundationAward: 2023TQ0080
- I-Innosuisse - Schweizerische Agentur für Innovationsförderung