UV-Mediated Enzyme-Like Activity Reversal Strategy To Regulate Nanozymes for Detection and Elimination of Bacteria

Nanozyme-based biosensing has gained a great deal of attention in various fields. However, most peroxidase-like (POD-like) nanozymes exhibit excellent enzyme-like activity, relying heavily on acidic environments, and their activity decays sharply in neutral or alkaline scenarios, posing a substantive challenge in more extensive applications. Herein, we propose an ultraviolet (UV)-mediated enzyme-like activity reversal strategy to regulate Fe3O4/CDs nanozyme, greatly recovering the enzyme-like activity of nanozymes in neutral/weakly alkaline environments. Specifically, UV irradiation of the nanozyme induces the transition of valence band electrons to the conduction band under neutral/weakly alkaline conditions.…

• NN
  National Natural Science Foundation of China

  Awards: 82172345, 22474124, 81573220
• NS
  Natural Science Foundation of Jiangsu Province

  Awards: BK20221281, BK20221370
• YU
  Yangzhou University

  Award: YZ2023204
• DO
  Department of Education of Guizhou Province

  Award: Qianjiaoji [2023]073
• SK
  State Key Laboratory of Analytical Chemistry for Life Sciences

  Award: SKLACLS2405
• YC
  Yangzhou City Agricultural Key R and D Program

  Award: YZ2023204