Innovative Strategies to Overcome Stability Challenges of Single-Atom Nanozymes

Single-atom nanozymes (SAzymes) exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metal-carrier interactions, which have attracted significant attention in the biomedical field. However, stability issues may impede the clinical translation of SAzymes. This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields, including disease diagnosis (e.g., biosensors and diagnostic imaging), antitumor therapy (e.g., photothermal therapy, photodynamic therapy, sonodynamic therapy, and immunotherapy), antimicrobial therapy, and anti-oxidative stress therapy. More importantly, the existing challenges of SAzymes are…

• NN
  National Natural Science Foundation of China

  Award: 82003956
• ZU
  Zhengzhou University
• NK
  National Key Research and Development Program of China

  Award: 2022YFA1205802