The gut-lung axis: effects and mechanisms of gut microbiota on pulmonary diseases

The proposal of the gut-lung axis has profoundly reshaped our understanding of the mechanisms underlying respiratory diseases. As a crucial component of this axis, the gut microbiota plays a central role in pulmonary immune regulation through inter-organ communication mediated by metabolic products. However, a systematic integration of mechanisms explaining how gut microbes achieve precise cross-organ immune regulation remains elusive. Existing research predominantly focuses on descriptive observations, such as the association between early-life microbiota dysbiosis and an increased risk of asthma and chronic obstructive pulmonary disease (COPD), as well as the frequent occurrence of acute respiratory distress…

• NN
  National Natural Science Foundation of China

  Awards: CARS-35, 32030101
• SF
  Science Fund for Distinguished Young Scholars of Heilongjiang Province