Stimuli-responsive hydrogels based on cascade reactions: a novel strategy to promote the efficient repair of diabetic wounds
Yantai University · Liaoning Provincial People's Hospital · +1 more institution
Abstract
The impaired healing of diabetic wounds is caused by complex multifactorial pathologies and conventional therapeutic approaches often show limited efficacy. In recent years, stimulus-responsive hydrogels based on cascade reactions have become a promising approach in the management of diabetic wounds. These hydrogels are designed to react to particular characteristics of the wound microenvironment, such as glucose concentration, pH, reactive oxygen species (ROS) and enzyme activity, allowing spatiotemporally controlled drug release and synergistic multi-target control. This review focuses on the recent development in understanding of the pathophysiology of diabetic wounds, immune microenvironment modulation,…
Citation impact
- FWCI
- 57.15
- Percentile
- 100%
- References
- 0
Authors
6- JJJialin JiaCorresponding
Yantai University, Liaoning Provincial People's Hospital, China Medical University
- XWXiaosu Wang
Yantai University, Liaoning Provincial People's Hospital, China Medical University
- TZTao Zhang
Yantai University
- QSQingxia Sun
Liaoning Provincial People's Hospital, China Medical University
- SYShude Yang
Liaoning Provincial People's Hospital, China Medical University
Topics & keywords
- Self-healing hydrogels
- Cascade
- Wound healing
- Immune system
- Inflammation
- Reactive oxygen species