articleJournal of NeurochemistryJan 1, 2026HYBRID OA

The Enteric Nervous System as a Mediator of Microbiota‐Gut‐Brain Interactions in Parkinson's Disease

LVLuisa ValdetaroMCMaria Carolina RicciardiPGP. G AlmeidaMBMilena Barcza Stockler‐PintoALAna Lúcia Tavares‐Gomes

Universidade Federal Fluminense

PubMed
Indexed incrossrefpubmed

Abstract

Parkinson's disease (PD) is a multifactorial neurodegenerative disorder in which gastrointestinal dysfunction is highly prevalent and often precedes motor symptoms. Although research on gut microbiota alterations in PD has expanded rapidly, inconsistent findings and the absence of a reproducible microbial signature reveal the limitations of a microbiota-centered view. The enteric nervous system (ENS), the intrinsic neural network of the gut, has been comparatively overlooked and remains underexplored, yet mounting evidence indicates that it undergoes profound alterations in PD. Pathological changes in enteric neurons and glial cells, including α-synuclein accumulation, disrupted neurotransmission, impaired…

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Topics & keywords

Topics
Keywords
  • Enteric nervous system
  • Mediator
  • Dysbiosis
  • Context (archaeology)
  • Disease
  • Gut–brain axis
  • Immune system
  • Central nervous system
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