articleNature MedicineJan 5, 2026HYBRID OA

A minimally invasive dried blood spot biomarker test for the detection of Alzheimer’s disease pathology

HHHanna HuberLMLaia Montoliu-GayaWSWagner S. BrumJVJakub VávraYYYara Yakoub

University Hospital Bonn · German Center for Neurodegenerative Diseases · +27 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Abstract Blood biomarkers have emerged as accurate tools for detecting Alzheimer’s disease (AD) pathology, offering a minimally invasive alternative to traditional diagnostic methods such as imaging and cerebrospinal fluid (CSF) analysis. Yet, the logistics surrounding venipuncture for blood collection, although considerably simpler than the acquisition of imaging and CSF, require precise processing and storage specific to AD biomarkers that are still guided by medical personnel. Consequently, limitations in their widescale use in research and broader clinical implementation exist. The DROP-AD project investigates the potential of dried plasma spot (DPS) and dried blood spot (DBS) analysis, derived from…

Citation impact

7
total citations
FWCI
48.29
Percentile
100%
References
42
Too recent for citation history.

Authors

48

Topics & keywords

Topics
Keywords
  • Venipuncture
  • Dried blood spot
  • Biomarker
  • Venous blood
  • Asymptomatic
  • Blood test
  • Population
  • Neurofilament
No related works found for this paper.

Funding