The role of ER-associated degradation and ER-phagy in health and disease
Chungnam National University · National University College · +1 more institution
Abstract
The endoplasmic reticulum (ER) is a major cellular organelle for the synthesis and folding of secretory and transmembrane proteins, whose proper function underpins organellar homeostasis, proper tissue function, and organismal physiology. Protein quality control (PQC) systems at the ER include the unfolded protein response (UPR), ER-associated degradation (ERAD), and ER-phagy, which monitor ER homeostasis and contribute to protein refolding, sequestration, or degradation. ERAD prevents the accumulation of misfolded or orphan proteins that would otherwise be toxic. By controlling the degradation of these proteins, ERAD performs a core function in governing adaptation to proteotoxic stress. ERAD also regulates…
Citation impact
- FWCI
- 67.08
- Percentile
- 100%
- References
- 545
Authors
2Topics & keywords
- Endoplasmic-reticulum-associated protein degradation
- Endoplasmic reticulum
- Unfolded protein response
- Protein folding
- Protein degradation
- Transmembrane protein
- Function (biology)
- Proteostasis