Bone turnover markers (β-CTX, PINP, ALP) in osteoporosis: correlation with bone loss and fracture risk stratification

Objective To investigate the correlation of β-C-terminal telopeptide of type I collagen (β-CTX), procollagen type I N-terminal propeptide (PINP), alkaline phosphatase (ALP) with bone mineral density (BMD) in patients with osteoporosis and evaluate their predictive value for secondary fracture risk. Methods A total of 180 osteoporosis patients and 80 healthy controls were enrolled. The osteoporosis group was stratified into fracture and non-fracture cohorts. Correlation of β-CTX, PINP, ALP with BMD at lumbar spine (L1-4) and femoral neck was assessed using Pearson correlation coefficient. Binary logistic regression model was employed to analyze the risk factors associated with secondary fractures in patients…

• FP
  Fujian Provincial Department of Science and Technology

  Award: 2021J1274