Lysosome-Targeted Dual-Functional Probe Capable of Detecting Acute Kidney Injury via In Vivo Imaging and Urinary Albumin Detection

Drug-induced acute kidney injury (AKI) emerged as a pressing global health concern, necessitating the urgent development of sensitive, in situ, in vivo detection methods. Fluorescent probes demonstrated attractive advantages in disease diagnosis, particularly dual-target responsive fluorescent probes that provide superior reliability. This paper presents a lysosome-targeted dual-functional fluorescent probe, MDSM-L, suitable for quantitative detection of serum/urine albumin and real-time in vivo detection of drug-induced AKI. MDSM-L exhibits sensitive fluorescence activation characteristics for serum albumin and viscosity at 675 and 710 nm, respectively, enabling successful fluorescence detection of BSA and…

• NN
  National Natural Science Foundation of China

  Award: 22077044
• FR
  Fundamental Research Funds for the Central Universities

  Award: CCNU24JCPT021