Oxidative Potential of Atmospheric Particulate Matter: A Review of the Role of Metal−Organic Interactions, Mechanistic Insights, and Key Determinants
Hong Kong University of Science and Technology · Department of the Environment · +1 more institution
Abstract
Oxidative stress, resulting from antioxidant depletion or excessive reactive oxygen species (ROS) production, is a key mechanism linking ambient particulate matter (PM) exposure to adverse health effects. The oxidative potential (OP) of PM, a measure of inhaled PM's capacity to deplete antioxidants or generate ROS, is largely driven by transition metals (TMs) such as iron and copper. However, coexisting organic matter also modulates OP, both directly through its own redox activity and indirectly via interactions with TMs that alter redox cycling. This review synthesizes current understanding of TM-organic interactions and their influence on the OP of PM, as assessed by acellular assays. We discuss mechanistic…
Citation impact
- FWCI
- 81.64
- Percentile
- 100%
- References
- 106
Authors
2- MLManfei LinCorresponding
Hong Kong University of Science and Technology, Department of the Environment, Jiangsu Provincial Academy of Environmental Science
- JZJ. Z. Yu
Hong Kong University of Science and Technology, Department of the Environment
Topics & keywords
- Particulates
- Redox
- Reactive oxygen species
- Mechanism (biology)
- Oxidative stress
- Oxidative phosphorylation