Identification of diagnostic biomarkers for ischemic stroke and drug targets of Buyang Huanwu decoction: A bioinformatics and network pharmacology study
Chongqing University · Zhejiang Industry Polytechnic College · +5 more institutions
Abstract
Buyang Huanwu decoction (BHD) is extensively employed in the management of ischemic stroke (IS), yet its drug targets and mechanisms of action in IS remain obscure. Thus, in this investigation, network pharmacology and computational biology techniques were employed to investigate the drug targets of BHD in the management of IS. This study aims to identify diagnostic biomarkers for IS and to elucidate the potential drug target network of BHD using integrated bioinformatics and network pharmacology approaches. mRNA expression profiles (GSE16561, GSE58294) were retrieved from the Gene Expression Omnibus (GEO). BHD compounds were obtained from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database…
Citation impact
- FWCI
- 166.93
- Percentile
- 100%
- References
- 29
Authors
7- SFShun Fu
Chongqing University, Zhejiang Industry Polytechnic College, China Coal Technology and Engineering Group Corp (China)
- WTWensheng Tang
Zhejiang Industry Polytechnic College
- SLShisui Luo
China Coal Technology and Engineering Group Corp (China)
- WWW. Wang
Dalian Medical University, Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University
- YHYin Huang
The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing Medical University
Topics & keywords
- Systems pharmacology
- KEGG
- Gene co-expression network
- Identification (biology)
- Drug
- Systems biology
- Pharmacogenomics
- Gene expression profiling
- Good health and well-being