Zn glycine attenuates LPS-induced inflammatory bone loss in geese through suppression of osteoclastogenesis via reducing TLR-4/NFκB signaling

Lipopolysaccharide (LPS), a major component of the outer membrane of gram-negative bacteria such as Escherichia coli, disrupts gut microbial homeostasis, compromises intestinal barrier integrity, and contributes to inflammation-associated bone loss. Although the gut-bone axis is increasingly recognized as a critical regulator of skeletal health, effective nutritional strategies targeting this pathway remain insufficiently explored. This study investigated the protective effects of Zn glycine, a highly bioavailable organic zinc chelates, against LPS-induced inflammatory bone loss in meat geese. Dietary supplementation with Zn glycine at 80 mg/kg significantly alleviated LPS-induced growth impairment, intestinal…

• HA
  Henan Agricultural University
• AR
  Agriculture Research System of China
• MO
  Ministry of Agriculture and Rural Affairs of the People's Republic of China

  Awards: 244200510010, CARS-34