Heterogeneity-Aware, Multiscale Annotation of Shared and Specific Neurobiological Signatures among Major Neurodevelopmental Disorders
South China University of Technology · First Affiliated Hospital of Guangzhou Medical University · +6 more institutions
Abstract
Autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and schizophrenia (SCZ) represent major neurodevelopmental disorders with distinct typical ages of onset. These disorders exhibit substantial genetic and phenotypic overlap, yet their shared and disorder-specific neurobiological mechanisms remain unclear. We analyzed resting-state functional magnetic resonance imaging data from 2,176 participants (ASD, ADHD, SCZ, and healthy controls). Using heterogeneous matrix factorization, we extracted meta-blood-oxygen-level-dependent signals to reduce individual heterogeneity and constructed functional connectivity networks. Partial least squares identified a shared transdiagnostic abnormal…
Citation impact
- FWCI
- 79.04
- Percentile
- 100%
- References
- 110
Authors
12- YDY. DiaoCorresponding
South China University of Technology
- YHYuanyuan Huang
First Affiliated Hospital of Guangzhou Medical University, Guangzhou Psychiatric Hospital, Guangdong 999 Brain Hospital, Guangzhou Medical University
- BZBaoyuan Zhu
South China University of Technology
- MGMinxin Guo
South China University of Technology
- WWWei Wang
South China University of Technology
Topics & keywords
- Autism spectrum disorder
- Schizophrenia (object-oriented programming)
- Glutamatergic
- Autism
- Serotonin transporter
- Functional magnetic resonance imaging
- Bipolar disorder
- Functional connectivity