articleOrganic LettersJan 8, 2026Closed access

Photodriven Fluoroalkylation–Alkoxylation of Enol Ethers via Electron Donor–Acceptor Complex of Bromodifluoroacetamides

WSWeijie SiZWZhanghong WangHYHongyi YangWYWen-Chao Yang

Institute of Molecular Functional Materials · Anyang Normal University · +4 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

We herein describe an unprecedented photoinduced EDA-enabled multicomponent reaction for the construction of fluorinated acetals from enol ethers, bromodifluoroacetamides, and alcohols, which enables late-stage functionalization of acetals. This reaction involved a cascade XAT/radical addition/SET/alkoxylation process. The reaction exhibited a broad substrate scope and a wide functional group compatibility.

Citation impact

9
total citations
FWCI
104.27
Percentile
100%
References
52
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Authors

4

Topics & keywords

Topics
Keywords
  • Enol
  • Cascade
  • Substrate (aquarium)
  • Surface modification
  • Scope (computer science)
  • Cascade reaction
  • Functional group
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