An expanded registry of candidate cis-regulatory elements

Abstract Mammalian genomes contain millions of regulatory elements that control the complex patterns of gene expression 1 . Previously, the ENCODE consortium mapped biochemical signals across hundreds of cell types and tissues and integrated these data to develop a registry containing 0.9 million human and 300,000 mouse candidate cis -regulatory elements (cCREs) annotated with potential functions 2 . Here we have expanded the registry to include 2.37 million human and 967,000 mouse cCREs, leveraging new ENCODE datasets and enhanced computational methods. This expanded registry covers hundreds of unique cell and tissue types, providing a comprehensive understanding of gene regulation. Functional…