Immune profiling in a living human recipient of a gene-edited pig kidney

Xenotransplantation of gene-edited pig kidneys offers a promising solution to the shortage of kidneys for organ transplantation. We recently performed a gene-edited pig kidney transplantation into a living human recipient with end-stage kidney disease. Here, using transcriptomics, proteomics, metabolomics and multiplexed imaging, we conducted high-dimensional immune profiling in this individual. Despite profound depletion of circulating T cells, early T cell-mediated rejection occurred within 1 week after transplantation, likely driven by subtherapeutic immunosuppression and the presence of residual CD8+ T cells in lymph nodes. This T cell-mediated rejection event was reversed by intensified immunosuppression.…

• MG
  Massachusetts General Hospital
• DO
  Division of Intramural Research, National Institute of Allergy and Infectious Diseases

  Award: R01AI143887
• FD
  Fundação de Amparo à Pesquisa do Estado de São Paulo

  Award: 2018/14933-2
• CN
  Conselho Nacional de Desenvolvimento Científico e Tecnológico