Stirring the Debate: How Mixing Influences Reproducibility and Efficiency in Synthetic Organic Chemistry

Schuurmans, Jasper H. A.; Zondag, Stefan D. A.; Chaudhuri, Arnab; Schaaf, John van der; Noël, Timothy

doi:10.1021/acscentsci.5c01825

articleACS Central ScienceJan 6, 2026DIAMOND OA

Stirring the Debate: How Mixing Influences Reproducibility and Efficiency in Synthetic Organic Chemistry

JHJasper H. A. Schuurmans SDStefan D. A. Zondag ACArnab Chaudhuri JVJohn van der SchaafTNTimothy Noël

Flow Analysis (United States) · Vrije Universiteit Amsterdam · +4 more institutions

PubMed

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Abstract

Mixing is essential in chemical processes, ensuring the proximity and interaction of reactants. Recent reports suggest stirring may minimally affect some solution-phase organic reactions, but this oversimplifies mixing's complexity. We discuss its principles, relevance to organic synthesis, and practical considerations for reproducibility and safety. Even if some reactions seem agitation-insensitive, mixing remains crucial for reproducibility, scalability, and industrial applications.

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7

total citations

FWCI: 58.67
Percentile: 100%
References: 60

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Authors

5

JH
Jasper H. A. Schuurmans
Flow Analysis (United States), Vrije Universiteit Amsterdam, University of Amsterdam
SD
Stefan D. A. Zondag
Sustainable Energy Systems (United Kingdom), Eindhoven University of Technology
AC
Arnab Chaudhuri
Maastricht University
JV
John van der SchaafCorresponding
Sustainable Energy Systems (United Kingdom), Eindhoven University of Technology
TN
Timothy NoëlCorresponding
Flow Analysis (United States), Vrije Universiteit Amsterdam, University of Amsterdam

Topics & keywords

Topics

Keywords

Mixing (physics)
Reproducibility
Organic synthesis
Relevance (law)
Organic chemicals

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