Mitochondria and the Actin Cytoskeleton in Neurodegeneration
University of Pittsburgh · IIT@MIT
Abstract
Mitochondrial dysfunction and cytoskeletal disorganization are widely recognized hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS). Although these disorders differ in clinical presentation and etiology, accumulating evidence points to a shared cellular vulnerability at the intersection of mitochondrial dynamics and actin cytoskeletal regulation. In this review, we examine the emerging role of actin-mitochondria crosstalk as a convergent mechanism in neurodegeneration. We discuss how disruptions in actin filament remodeling, mitochondrial fission and fusion, organelle transport, and mitophagy…
Citation impact
- FWCI
- 41.36
- Percentile
- 99%
- References
- 60
Authors
4Topics & keywords
- Neurodegeneration
- Mitophagy
- Crosstalk
- Cytoskeleton
- Mitochondrion
- Actin
- Actin cytoskeleton
- Mitochondrial fission