Multilayered regulation of cytoskeletal protein abundance: autoregulatory mechanisms of actin and tubulin
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Abstract
Structural proteins such as actin and tubulin form the fundamental framework of the cytoskeleton and are essential for diverse cellular processes, including morphogenesis, intracellular transport and cell division. Maintaining precise intracellular levels is crucial for cellular homeostasis because both excess and deficiency can lead to cytotoxicity. Although transcriptional regulation establishes basal expression levels, recent studies have highlighted the crucial role of post-transcriptional and post-translational mechanisms in the fine-tuning of cytoskeletal protein abundance in response to dynamic cellular demands. Actin and tubulin use distinct autoregulatory strategies. Tubulin mRNA undergoes…
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4
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2Topics & keywords
Topics
Keywords
- Cytoskeleton
- Tubulin
- Microtubule
- Actin
- Actin remodeling
- Intracellular
- Actin cytoskeleton
- Profilin
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