articleJournal of the Endocrine SocietyJan 8, 2026GOLD OA

Assessment of N/L ratio and subclinical atherosclerosis in FH subjects with or without LDLR mutation

FBFrancesco BarbagalloGBGiosiana BoscoMDMaurizio Di MarcoSSSabrina ScillettaNMNicoletta Miano

Università degli Studi di Enna Kore · University of Catania

PubMed
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Abstract

Abstract Background Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-density lipoprotein-cholesterol (LDL-C) and increased cardiovascular risk. While the role of LDL-C in atherogenesis is well established, the contribution of inflammatory activation in FH, particularly in relation to genotype, remains poorly defined. We aimed to evaluate the impact of genotype on neutrophil-to-lymphocyte ratio (NLR) and on subclinical atherosclerosis in a cohort of FH subjects. Methods We conducted a cross-sectional study on 423 FH subjects not on lipid-lowering therapy and free from atherosclerotic cardiovascular disease. Biochemical, genetic, and vascular assessments were performed in…

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100%
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16

Topics & keywords

Topics
Keywords
  • LDL receptor
  • Subclinical infection
  • Biomarker
  • Mutation
  • Familial hypercholesterolemia
UN Sustainable Development Goals
  • Good health and well-being
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