PET/CT imaging of tuberculosis lung lesions in marmosets treated with different drug regimens aligns with human clinical outcomes

Early bactericidal activity and time to sputum conversion are well-established study end points in both preclinical animal models and clinical trials for testing drug regimens for pulmonary tuberculosis (TB). The development and optimization of treatment-shortening drug regimens for TB have been challenged by disparities between these study end points and nonrelapsing cure. We hypothesized that using lung lesions measured by 2-deoxy-2-[ 18 F]fluoro- d -glucose–positron emission tomography/computed tomography (PET/CT) imaging in infected marmosets could help to interpret treatment efficacies and better understand clinical treatment outcomes. Radiographic changes in lung lesions were measured using PET/CT…

• BA
  Bill and Melinda Gates Foundation

  Awards: INV-027276, INV-010245
• NI
  National Institutes of Health

  Award: R01AI150684