SIRT1: The first key to unlocking the mystery of cardiovascular diseases
Ministry of Education of the People's Republic of China · Harbin Medical University · +4 more institutions
Abstract
Cardiovascular disease, (CVD) the leading cause of death worldwide, encompasses various heart and vascular disorders that significantly elevate morbidity and mortality rates. Sirtuin 1 (SIRT1), a NAD + dependent deacetylase, plays a key role in cardiovascular health and pathology by regulating fundamental processes such as endothelial function, oxidative stress, inflammation, senescence, metabolism, cardiac hypertrophy, and heart failure. Through these mechanisms, SIRT1 emerges as critical factor in the pathophysiology of CVDs, including heart failure, atherosclerosis, hypertension, and myocardial infarction. SIRT1 modulates several cellular pathways to regulate complex cellular processes associated with…
Citation impact
- FWCI
- 46.50
- Percentile
- 99%
- References
- 310
Authors
11- KDKhuzin Dinislam
Ministry of Education of the People's Republic of China, Harbin Medical University, Chinese Academy of Medical Sciences & Peking Union Medical College, Ministry of Health of the Russian Federation, Bashkir State Medical University, Second Affiliated Hospital of Harbin Medical University
- MAMuneer Ahmed Khoso
Ministry of Education of the People's Republic of China, Harbin Medical University, Chinese Academy of Medical Sciences & Peking Union Medical College, Second Affiliated Hospital of Harbin Medical University
- VAValeriy A. Kataev
Ministry of Health of the Russian Federation, Bashkir State Medical University
- SMS. M. Meshcheryakova
Ministry of Health of the Russian Federation, Bashkir State Medical University
- HLHeng Liu
Ministry of Education of the People's Republic of China, Harbin Medical University, Chinese Academy of Medical Sciences & Peking Union Medical College, Second Affiliated Hospital of Harbin Medical University
Topics & keywords
- Sirtuin
- Sirtuin 1
- Pathological
- Cardiovascular health
- Pathophysiology
- Disease
- Cause of death
- Endothelial dysfunction
- Good health and well-being