A meta-analysis of the effects of vitamin D supplementation on endocrine metabolic and inflammatory markers in patients with polycystic ovarian syndrome

To evaluate the effects of vitamin D on the endocrine, metabolic, and inflammatory markers providing new PCOS treatment ideas.

PubMed, EMBASE, Web of Science, and Cochrane Library were systematically searched for vitamin D treatment studies in PCOS patients from establishment to 12/2022 using vitamin D, polycystic ovary syndrome, PCOS, etc, as search terms. Two researchers independently screened the retrieved literature, extracted the data, and finally performed a meta-analysis of these data with Review Manager 5.4 software to calculate all-parameter weighted mean difference (WMDs) and 95% confidence intervals (CIs) using a fixed-effects or random-effect models.