articleJAMAJan 7, 2026Closed access

Sibling Comparisons to Account for Confounding in Observational Studies

Aarhus University · Karolinska Institutet · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

This JAMA Guide to Statistics and Methods explains how sibling analysis can be used to account for confounding in observational studies, using the example of a study on acid suppressants during pregnancy and risk of neuropsychiatric disorders in offspring.

Citation impact

6
total citations
FWCI
135.07
Percentile
100%
References
9
Too recent for citation history.

Authors

3

Topics & keywords

Keywords
  • Observational study
  • Confounding
  • Sibling
  • Pregnancy
  • MEDLINE
  • Cohort study
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