Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases
Fudan University · Fudan University Shanghai Cancer Center · +1 more institution
Abstract
Organ cross-talk, also known as the organ axis or organ interaction network, plays a vital role in maintaining physiological homeostasis and responding to environmental stimuli. This review comprehensively integrates cutting-edge observations in organ communication research, with a particular focus on the brain, heart, and gut-the three core organs that garner the most attention in organ connection studies. The current state of organ interaction network research is clearly presented as a Sankey diagram. For brain-related connections, the interactions among the brain-gut, brain-liver, and brain-heart connections are thoroughly reviewed; for heart-related connections, the relationships among the heart-kidney,…
Citation impact
- FWCI
- 99.09
- Percentile
- 100%
- References
- 516
Authors
6Topics & keywords
- Organ system
- Systems biology
- Mechanism (biology)
- Disease
- Psychological intervention
- Value (mathematics)
- Personalized medicine
- Variety (cybernetics)