A Universal Metal–Flavonoid Coating Strategy: Engineering Biomaterials for Diabetic Bone Regeneration
Wenzhou University · Wenzhou Medical University · +6 more institutions
Abstract
Under metabolic disorders such as diabetes, the regenerative capacity of bone tissue is compromised, characterized by hyperglycemia-induced oxidative stress, impaired osteogenesis, and dysregulated angiogenesis. These complications undermine the efficacy of conventional bone repair materials, limiting their capacity to promote effective healing. Herein, we developed a metal-flavonoid functionalized coating strategy that integrates osteogenic and angiogenic metal ions with natural antioxidant flavonoids. Leveraging their chelation ability and strong surface affinity, a one-pot approach is established to endow conventional bone repair materials with tailored biofunctions that modulate the diabetic bone…
Citation impact
- FWCI
- 40.84
- Percentile
- 100%
- References
- 48
Authors
12- CYChen YangCorresponding
Wenzhou University, Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, Soochow University, First Affiliated Hospital of Soochow University
- CQC Q Dong
Wenzhou University, Huazhong University of Science and Technology
- LSLefeng Su
Wenzhou University
- ZLZhiqiang Liu
Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University
- LHLingyi Hu
Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University
Topics & keywords
- Coating
- Bone healing
- Biomaterial
- Regenerative medicine
- Angiogenesis
- Mesenchymal stem cell
- Tissue engineering
- Regeneration (biology)