Engineering Metallic Implants with Self-Catalytic Degradable Bionanozyme Coating and Ion-Releasing Biointerface for Bioadaptive Anti-infective and Osteogenic Functionality

Implant-associated infections and poor osseointegration remain major challenges for Ti-based indwelling devices. To address these, we developed a multifunctional implant coating integrating photothermal-enhanced nanobioenzymatic catalysis with degradable release of bioactive components for staged antibacterial and osteogenic functions. The coating consisted of a Ca2+/Cu2+-doped micro/nanostructured titanate layer overlaid with a bionanozyme (HMG)-loaded, alendronate-modified hyaluronic acid (AHA) matrix, anchored via Ca2+–alendronate chelation. The bionanozyme HMG comprised glucose oxidase (GOx) encapsulated in hollow MnO2 nanozymes and stabilized by tannic acid (TA). Upon infection, GOx-generated H2O2 (from…

• GP
  Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument

  Award: 2020B1212060077
• NN
  National Natural Science Foundation of China

  Awards: 52201303, 22205012, 52571277
• SS
  Shenzhen Science and Technology Innovation Program

  Awards: JCYJ20250604174721028, JCYJ20220530145603007
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Awards: 2023A1515012951, 2025A1515010596