articleMolecular BiomedicineJan 9, 2026DIAMOND OA

Ionizing radiation: molecular mechanisms, biological effects, and therapeutic targets

WWWei WeiYRYifan RenJLJinxin LanJYJieyu YiMCM C Wang

Chinese PLA General Hospital · Nankai University · +3 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Radiation-induced injury remains a significant challenge in the radiotherapy of cancer patients. Ionizing radiation causes various cellular and molecular damages, leading to both acute and chronic organ dysfunction. Its impact extends beyond interrupting standard treatment protocols and adversely affects the quality of life. Therefore, understanding the mechanisms underlying radiation-induced injury and identifying effective treatment strategies are crucial. In this review, we summarize the recent advances in the molecular and cellular mechanisms of radiation-induced injury across various organs and systems, particularly in the lung, gastrointestinal system, brain, skin, and bone. We highlight the roles of…

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5
total citations
FWCI
92.35
Percentile
100%
References
212
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Authors

14

Topics & keywords

Topics
Keywords
  • DNA damage
  • Epigenetics
  • Cancer
  • Radiation therapy
  • Radiation injury
  • Mechanism (biology)
  • Ionizing radiation
  • DNA repair
UN Sustainable Development Goals
  • Good health and well-being
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