Chinese Immune Multi-Omics Atlas

Yin, Jianhua; Zheng, Yuhui; Huang, Zhuoli; Zhou, Wenwen; Yuan, Yue; Cai, Pengfei; Bai, Yong; Yang, Shichen; Gao, Yue; Duan, Shanshan; Wang, Yang; Xu, Zekai; Zhang, W H; Zhang, Xinyu; Wei, Yilin; Huang, Yaling; Liu, Ying; Wang, Weikai; Yang, Tao; Zhang, Zhongjin; Chen, Xiaoya; Zhang, Xiru; Lv, Jingzhi; Li, Fupeng; Zhang, Yan; Zeng, Guodan; Wang, Xue; Ma, Wen; Hou, Guixue; Hao, Shijie; Liu, Chang; Lai, Yiwei; Liu, Panhong; Wang, Bo; Li, Yuxiang; Zhang, Wenwei; Gao, Peng; Xie, Jun; Esteban, Miguel A.; Gu, Ying; Liu, Xin; Ji, Jiansong; Qi, Ting; Liu, Boxiang; Wang, Hua; Zhao, Yi; Yang, Xiao; Wang, X. F.; Chen, Runsheng; Yang, Jian; Yin, Ye; Wang, J; Cao, Yanan; Xu, Xun; Liu, Longqi; Xh, Jin; Liu, Chuanyu

doi:10.1126/science.adt3130

articleScienceJan 8, 2026Closed access

Chinese Immune Multi-Omics Atlas

JYJianhua Yin YZYuhui ZhengZHZhuoli HuangWZWenwen Zhou YYYue Yuan

BGI Group (China) · Shanxi Medical University · +25 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Human peripheral blood exhibits molecular and cellular heterogeneity across populations, yet the underlying mechanisms remain unclear. We present the Chinese Immune Multi-Omics Atlas (CIMA), characterizing molecular variations linked to sex, age, and genetic variants through multi-omics analysis of more than 10 million circulating immune cells from 428 Chinese adults. CIMA established an enhancer-driven gene regulatory network comprising 237 robust regulons; identified 9600 eGenes and 52,361 caPeaks at cell type resolution; and revealed pleiotropic associations among immune-related disease risk loci, cis-expression quantitative trait loci (QTLs), and chromatin accessibility QTLs. Furthermore, the cell language…

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7

total citations

FWCI: 91.31
Percentile: 100%
References: 128

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Authors

57

JY
Jianhua YinCorresponding
BGI Group (China), Shanxi Medical University
YZ
Yuhui Zheng
BGI Group (China), University of Chinese Academy of Sciences, BGI Research
ZH
Zhuoli Huang
BGI Group (China), University of Chinese Academy of Sciences, BGI Research
WZ
Wenwen Zhou
BGI Group (China), University of Chinese Academy of Sciences, BGI Research
YY
Yue Yuan
BGI Group (China), State Key Laboratory of Chemical Engineering, BGI Research

Topics & keywords

Topics

Keywords

Chromatin
Immune system
Gene
Cell type
Quantitative trait locus
Disease
Cell
Peripheral blood

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