Acetaminophen (Paracetamol) or Opioid Analgesia Added to Ibuprofen for Children’s Musculoskeletal Injury
University of Alberta · Women and Children’s Health Research Institute · +20 more institutions
Abstract
Ibuprofen is first-line therapy for musculoskeletal pain. However, two-thirds of children experience inadequate pain relief with ibuprofen monotherapy, and the efficacy of additive medications for moderate to severe musculoskeletal pain is unclear.
To determine whether treatment with an opioid (hydromorphone) plus ibuprofen or nonopioid (acetaminophen [paracetamol]) plus ibuprofen decreased pain scores compared with ibuprofen alone. Design, Setting, and Participants: Two randomized, double-masked, placebo-controlled trials were conducted from April 2019 to March 2023 in 6 university-affiliated, tertiary care Canadian pediatric emergency departments. Children aged 6 to 17 years presenting with a nonoperative acute limb injury (
Citation impact
- FWCI
- 115.43
- Percentile
- 100%
- References
- 36
Authors
38- SASamina AliCorresponding
University of Alberta, Women and Children’s Health Research Institute, Stollery Children's Hospital
- TPTerry P. Klassen
Saskatoon City Hospital, University of Saskatchewan
- PCPatricia Candelaria
University of Alberta, Stollery Children's Hospital
- MBMaala Bhatt
University of Ottawa, Children's Hospital of Eastern Ontario
- SSScott Sawyer
Children's Hospital Research Institute of Manitoba, Children's Hospital of Winnipeg, University of Manitoba
Topics & keywords
- Ibuprofen
- Acetaminophen
- Opioid
- Musculoskeletal injury
- Musculoskeletal pain
- Analgesic
- Good health and well-being