articleAging CellJan 8, 2026GOLD OA

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

SMSarah MorsyESEnzo ScifoKXKan XieKSKristina SchaafJRJenny Russ

German Center for Neurodegenerative Diseases · University of Bonn

PubMed
Indexed incrossrefdoajpubmed

Abstract

Aging, a major risk factor for numerous diseases, is associated with significant transcriptional changes across organs. However, the age of onset, extent of transcriptomic changes and how they unfold are not fully understood. We performed bulk RNA sequencing on eight organs (brain, heart, kidney, liver, lung, skeletal muscle, spleen, and testis) from male C57BL/6J mice across much of the murine lifespan covering 3-, 5-, 8-, 14-, 20- and 26-month-old animals. Our analysis revealed that age-related transcriptomic shifts vary in both timing and extent, with early shifts in lung, spleen, and testis; mid-life changes in heart, kidney, and skeletal muscle; and later alterations in brain and liver. The extent of…

Citation impact

5
total citations
FWCI
42.13
Percentile
100%
References
127
Too recent for citation history.

Authors

10

Topics & keywords

Topics
Keywords
  • Transcriptome
  • Gene
  • RNA-Seq
  • RNA
  • Gene expression
  • Extracellular matrix
  • Immune system
No related works found for this paper.

Funding