articleMoleculesJan 9, 2026GOLD OA

Advanced Technologies in Extracellular Vesicle Biosensing: Platforms, Standardization, and Clinical Translation

SCSeong-Jun ChoiJCJaewon ChoiJKJin KimSKSi-Hoon KimHCHyung-Geun Cho

Kangwon National University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Recently, extracellular vesicles (EVs) have emerged as pivotal mediators of intercellular communication that reflect physiological homeostasis and pathological alterations. By encapsulating diverse biomolecules, including proteins, nucleic acids, and lipids, EVs mirror the molecular signatures of their parent cells, thereby positioning EV-based biosensing as a transformative platform for noninvasive diagnostics, prognostic prediction, and therapeutic monitoring. This review provides a comprehensive overview of the current state and clinical translation of EV biosensing technologies. Herein, we have discussed ongoing efforts toward standardization and analytical validation (e.g., MISEV2023 and EV-TRACK) and…

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8
total citations
FWCI
74.76
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100%
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122
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10

Topics & keywords

Topics
Keywords
  • Extracellular vesicle
  • Extracellular vesicles
  • Standardization
  • Biosensor
  • Translation (biology)
  • Bench to bedside
  • Adaptation (eye)
  • Aptamer
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