articleBioorganic ChemistryJan 9, 2026Closed access

Discovery of novel pyridazinone derivatives as EGFRWT/ EGFRT790M kinase inhibitors; design, synthesis, antitumor evaluation, and molecular dynamic simulations

SYSara Y EwiedaEMEman M. AhmedPAPeter A. HalimSGShaymaa G. IbrahimKMKhaled M. Gouda

Cairo University · Egyptian Russian University · +3 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

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4
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33.36
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99%
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8

Topics & keywords

Topics
Keywords
  • Sorafenib
  • Doxorubicin
  • Kinase
  • Erlotinib
  • Cell cycle checkpoint
  • Docking (animal)
  • Cytotoxic T cell
  • Cell growth
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