articleAnalytical ChemistryJan 8, 2026Closed access

Metal–Organic Framework@Gold Nanoparticles Enables Point-of-Care Diagnostics To Have Comparable Analytical Performance to Chemiluminescent Immunoassays

FCFengli ChaiDWDou WangFLFenggang LiSWSaijie WangYCYao Chen

Beijing Institute of Technology · Southern University of Science and Technology · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Lateral flow immunoassay (LFIA) is a vital point-of-care testing (POCT) technique that is widely used for on-site detection and in vitro diagnosis. Many diseases, particularly cardiovascular diseases (CVDs), require the quantitative detection of multiple biomarkers across a broad dynamic range. Recurrent viral infections like COVID-19 elevate CVDs risk, necessitating early warning and prognostic monitoring, especially based on POCT of multiple blood biomarkers of D-dimer, NT-proBNP, and cTnI across a broad range from pg/mL to μg/mL. Traditional LFIAs lack ultrasensitivity and broad-range quantification. We design the surface chemistry-mediated template-free assembly of metal-aggregation-induced emission…

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Topics & keywords

Topics
Keywords
  • Chemiluminescence
  • Naked eye
  • Chromogenic
  • Immunoassay
  • Nanoparticle
  • Dynamic range
  • Surface plasmon resonance
  • Analyte
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