IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation
Korea Advanced Institute of Science and Technology · Yonsei University · +10 more institutions
Abstract
Identifying the cell of origin that harbors an initial driver mutation is key to understanding tumor evolution and for the development of new treatments. For isocitrate dehydrogenase (IDH)–mutant gliomas, the most common malignant primary brain tumor in young adults, the cell of origin is currently poorly understood. We conducted deep sequencing on 142 tissues from 70 individuals comprising tumors, peritumoral cortex or subventricular zones, and blood. Low-level IDH mutations were found in the peritumoral cortex in 37.9% (11 of 29) of patients. Integrating cell-type–specific mutation analysis, the direction of clonal evolution, spatial transcriptomics from patient brains, and a cancer mouse model arising from…
Citation impact
- FWCI
- 104.32
- Percentile
- 100%
- References
- 112
Authors
24- JWJung Won Park
Korea Advanced Institute of Science and Technology, Yonsei University, Severance Hospital
- JKJiehoon Kwak
Korea Advanced Institute of Science and Technology
- KWKeon Woo Kim
Korea Advanced Institute of Science and Technology
- SJST Jung
Korea Advanced Institute of Science and Technology
- CHChang Hyun Nam
Korea Advanced Institute of Science and Technology
Topics & keywords
- Subventricular zone
- Progenitor cell
- Mutation
- Isocitrate dehydrogenase
- Progenitor
- Glioma
- Mutant
- Transcriptome