The proportion of Alzheimer’s disease attributable to apolipoprotein E

Williams, Dylan M; Heikkinen, Sami; Hiltunen, Mikko; FinnGen; Davies, Neil M; Anderson, Emma L.

doi:10.1038/s44400-025-00045-9

articlenpj DementiaJan 9, 2026HYBRID OA

The proportion of Alzheimer’s disease attributable to apolipoprotein E

DMDylan M WilliamsSHSami HeikkinenMHMikko Hiltunen FFinnGen NMNeil M Davies

University of London · MRC Unit for Lifelong Health and Ageing · +3 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Abstract Variation in the APOE gene strongly affects Alzheimer’s disease (AD) risk. However, the proportion of AD burden attributable to this variation requires clarification, which would help to elucidate the scope of strategies targeting apolipoprotein E (APOE) for AD prevention and treatment. We estimated the extents to which clinically diagnosed AD, AD neuropathology and all-cause dementia are attributable to the common APOE alleles in four large studies. First, we used data on 171,105 and 289,150 participants aged ≥60 years from UK Biobank (UKB) and FinnGen, respectively. AD and all-cause dementia were ascertained from linked electronic health records in these cohorts. Second, we examined amyloid-β…

Citation impact

7

total citations

FWCI: 118.10
Percentile: 100%
References: 44

Too recent for citation history.

Authors

6

DM
Dylan M WilliamsCorresponding
University of London, MRC Unit for Lifelong Health and Ageing, University College London
SH
Sami Heikkinen
University of Eastern Finland
MH
Mikko Hiltunen
University of Eastern Finland
F
FinnGen
NM
Neil M Davies
University of London, Norwegian University of Science and Technology, University College London

Topics & keywords

Topics

Keywords

Neuropathology
Apolipoprotein E
Dementia
Attributable risk
Disease
Allele
Relative risk
Confidence interval

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.