Reprogramming immunity at the metabolic–epidermal interface in obesity-associated psoriasis
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Abstract
Obesity and psoriasis are chronic inflammatory disorders, now recognized to be interconnected, in which metabolic overload drives immune dysregulation and therapeutic resistance. Excess adiposity converts adipose tissue into an inflammatory organ that releases adipokines and cytokine-like mediators, reprogramming keratinocytes and immune cells to sustain cytokine-driven inflammatory circuits in the skin. Excess nutrients and lipotoxic stress impair mitochondrial function, enhance glycolysis, and induce epigenetic remodeling in myeloid and epithelial lineages, generating metabolic memory that perpetuates inflammation. Increased body mass index and insulin resistance are clinically associated with reduced…
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4
total citations
- FWCI
- 44.03
- Percentile
- 100%
- References
- 143
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4Topics & keywords
Topics
Keywords
- Psoriasis
- Inflammation
- Immune system
- Adipose tissue
- Innate immune system
- Tumor necrosis factor alpha
- Adipokine
- Immunity
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