Accelerated and Green Synthesis of N,S - and N,O -Heterocycles in Microdroplets

-heterocycles (thiazolines, oxazolines, thiazines, oxazines, aminothiazoles, and thiazolidines) in microdroplets. These chemical transformations occur under ambient conditions during the millisecond flight time of the droplets to the mass spectrometer for online analysis or deposition onto a collector surface. The intrinsic superacidity at the air-liquid interface of microdroplets facilitates the reaction and enables the formation of highly pure products without the need for additional purification, as evidenced by mass spectrometry (MS), infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR) analyses. High-throughput (HT) reaction screening based on desorption electrospray ionization (DESI) MS shows…

• NI
  National Institutes of Health

  Awards: NIH P30 CA023168, UG3/UH3 TR004139
• AF
  Air Force Office of Scientific Research

  Award: FA9550-21-1-0170