Early diagnosis and treatment of leptospirosis: Optimizing clinical outcomes

Highlights Leptospirosis has a therapeutic time window during early infection when patients are most likely to benefit from clinical interventions Early diagnosis is challenging because acute leptospirosis typically presents as an undifferentiated acute febrile illness Early recognition of patients at risk of severe disease is critical for guiding clinical management Human clinical trials consistently demonstrate benefits of early initiation of antibiotic therapy Implementing early diagnosis and treatment for leptospirosis requires an integrated approach to early detection, risk assessment, provider awareness, patient referral, and supportive care SummaryLeptospirosis is a globally prevalent zoonotic infection…

• CU
  Chulalongkorn University
• NI
  National Institutes of Health
• NI
  National Institute of Allergy and Infectious Diseases

  Awards: P01 AI168148, R01 AI183353