Wash-out as a Diagnostic Signal

Wash-out periods are commonly treated as technical necessities for safety or pharmacokinetic clearance. In clinical practice, however, important information often emerges during drug discontinuation and is frequently overlooked or misinterpreted. This paper reframes wash-out as a diagnostic signal rather than a passive interval. From a systems-level perspective, clinical change during active treatment reflects a superposition of direct pharmacological effects and endogenous system responses, which cannot be separated while the drug is present. Wash-out removes external pharmacological control while allowing system dynamics to continue, thereby distinguishing drug-driven effects from system-driven behavior.…