articleCell ProliferationJan 11, 2026GOLD OA

Vascularised Brain Organoids: Engineering Strategies and Neurobiological Applications

YSYeajin SongHJHyejin JoSJSeokchan JeongIKInseon KimSSSeunghun S. Lee

Dongguk University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Brain organoids have become an essential platform for studying human neural development and neurological disorders. Yet, one major limitation of conventional brain organoids is their lack of vascular structures. This deficiency restricts organoid size, contributes to necrotic core formation, and hampers their functional maturation. Introducing vascularization offers a compelling solution-it enhances nutrient delivery, supports neurogenesis, and fosters the development of interfaces that resemble the blood-brain barrier (BBB). In this review, we explore how vascularization enhances the structural and physiological relevance of brain organoids and its growing significance in disease modelling and therapeutic…

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4
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48.92
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99%
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128
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5

Topics & keywords

Topics
Keywords
  • Organoid
  • Human brain
  • Regenerative medicine
  • Human disease
  • Drug discovery
  • Drug development
  • Tissue engineering
  • Vascular network
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