articleAging CellJan 11, 2026GOLD OA

Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging

MMMadison MilanETEva Troyano‐RodriguezJIJennifer IhuomaSNSharon NegriRRRakesh Rudraboina

University of Oklahoma Health Sciences Center · University of Oklahoma · +3 more institutions

PubMed
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Abstract

Aging drives a progressive decline in vascular health, undermining endothelial function, neurovascular coupling (NVC), and blood-brain barrier (BBB) integrity, three processes essential for maintaining cerebral perfusion and cognitive resilience. Central to these age-related deficits is mitochondrial dysfunction, which disrupts redox balance, bioenergetics, and nutrient-sensing pathways within vascular cells, thereby promoting oxidative stress, impaired mitophagy, mitochondrial fragmentation, and endothelial senescence. These molecular derangements are especially consequential in the brain's microvasculature, where the exquisite metabolic demands of neural tissue depend on intact endothelial signaling. As a…

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Topics & keywords

Topics
Keywords
  • Mitochondrion
  • Cognitive decline
  • Rejuvenation
  • Mitochondrial biogenesis
  • Endothelium
  • Endothelial dysfunction
  • Oxidative stress
  • Mitochondrial ROS
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